Journal article
Group A Streptococcus pharyngitis and pharyngeal carriage: A meta-analysis
J Oliver, E Malliya Wadu, N Pierse, NJ Moreland, DA Williamson, MG Baker
Plos Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2018
Abstract
Objective: Antibiotic treatment of Group A Streptococcus (GAS) pharyngitis is important in acute rheumatic fever (ARF) prevention, however clinical guidelines for prescription vary. GAS carriers with acute viral infections may receive antibiotics unnecessarily. This review assessed the prevalence of GAS pharyngitis and carriage in different settings. Methods: A random-effects meta-analysis was performed. Prevalence estimates for GAS+ve pharyngitis, serologically-confirmed GAS pharyngitis and asymptomatic pharyngeal carriage were generated. Findings were stratified by age group, recruitment method and country income level. Medline and EMBASE databases were searched for relevant literature pub..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This study was supported by a grant from the New Zealand Lotteries Health Commission (https://www.communrtymatters.govt.nz/lottery-health-research/), in the form of a PhD scholarship awarded to National Health and Medical Research Council of Australia (https://www.nhmrc.gov.au/ GNT 1123854). NJM is supported by a New Zealand Heart Foundation Senior Research Fellowship (https://www.heartfoundahon.org.nz/).